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News-Medical.net news-medical.net 15 Sep, 2021 01:15 am

Researchers disprove natural antioxidant urate for slowing the progression of Parkinson’s disease

Researchers disprove natural antioxidant urate for slowing the progression of Parkinson’s disease
The hypothesis that raising the brain levels of the natural antioxidant urate could slow the progression of Parkinson's disease (PD) has been disproven by researchers at Massachusetts General Hospital.

The hypothesis that raising the brain levels of the natural antioxidant urate could slow the progression of Parkinson's disease (PD) has been disproven by researchers at Massachusetts General Hospital (MGH).Still, the rigor of the clinical study and some of its novel investigative approaches are seen as improving the prospects for future clinical trials to demonstrate the benefits of disease-modifying therapies for people with Parkinson's disease."The convergence of epidemiological, biological, and clinical data from past research made a compelling argument that elevating urate, the main antioxidant circulating in the blood, could protect against the oxidative damage thought to play a role in Parkinson's disease," says senior author Michael Schwarzschild, MD, PhD, a neurologist at MGH and co-leader of the MGH-based Parkinson Study Group, a network of North American researchers dedicated to improving therapy for people with PD." No treatment to date has been shown to prevent or forestall progression of Parkinson's disease, which affects the body's motor system.

For its Phase III trial, known as SURE-PD3, the MGH-led team enrolled 298 individuals recently diagnosed with early Parkinson's disease based on scans that indicated substantial loss of the dopamine-producing brain cells characteristic of PD.We also learned a lot in terms of clinical trials science for Parkinson's, and ways to conduct future studies that will increase their chance of success.

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