bignewsnetwork.com 06 Aug, 2022 19:30 am

How mutation functions in the brain, affects anxiety and sociality

New research using genome editing technology has allowed scientists to create a model and assess a gene mutation associated with neuropsychiatric disorders in h

Their evolutionary origins date back to metazoans, and while the function of related genes is strongly evolutionarily conserved, genetic variation within and between species has been reported to have a significant impact on animal mental characteristics such as sociality, aggression, anxiety, and depression.Previous reports suggested that people with the Ile genotype are less prone to depression and anxiety than those with the Thr genotype, but it was unclear how these human-specific mutations function in the brain and lead to changes in neuropsychiatric behavior.This study demonstrates the functional importance of human-specific variants in the regulatory circuits of neurotransmitters involved in cognitive and emotional functions and is expected to shed light on the pathogenic mechanisms of neuropsychiatric disorders such as anxiety and depression.Their evolutionary origins date back to metazoans, and while the function of related genes is strongly evolutionarily conserved, genetic variation within and between species has been reported to have a significant impact on animal mental characteristics such as sociality, aggression, anxiety, and depression.

Previous reports suggested that people with the Ile genotype are less prone to depression and anxiety than those with the Thr genotype, but it was unclear how these human-specific mutations function in the brain and lead to changes in neuropsychiatric behavior.This study demonstrates the functional importance of human-specific variants in the regulatory circuits of neurotransmitters involved in cognitive and emotional functions and is expected to shed light on the pathogenic mechanisms of neuropsychiatric disorders such as anxiety and depression.

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How mutation functions in the brain, affects anxiety and sociality

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