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northernirelandworld.com 11 Jan, 2022 14:00 am

Everything you need to know about xenotransplants as US man given pig heart

Everything you need to know about xenotransplants as US man given pig heart
In a medical first, doctors in the USA have transplanted a genetically modified pig heart into a human patient in an effort to save his life.

The surgery is a first of its kind (Photo: University of Maryland Medical Centre) In a medical first, doctors in the USA have transplanted a genetically modified pig heart into a human patient in an effort to save his life.At the University of Maryland Medical Centre (UMMC), a first of its kind transplant was successfully carried out wherein a 57-year-old man with terminal heart disease received a transplant of a genetically modified pig heart.Bartley P Griffith, who surgically transplanted the pig heart into Mr Bennett, said: “This was a breakthrough surgery and brings us one step closer to solving the organ shortage crisis.The UMMC said that the donor pig heart underwent a number of gene edits to ensure that it would not be rejected by Mr Bennett.

Six human genes that are responsible for the immune acceptance of the pig heart were then “inserted into the genome”.“Lastly, one additional gene in the pig was knocked out to prevent excessive growth of the pig heart tissue, which totaled 10 unique gene edits made in the donor pig,” the UMMC said.

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