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bmj.com 26 Nov, 2021 01:30 am

Association between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in England

Association between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in England

Harriet Forbes , assistant professor 1, Caroline E Morton , epidemiologist 2, Seb Bacon , chief technical officer 2, Helen I McDonald , assistant professor 1, Caroline Minassian , assistant professor 1, Jeremy P Brown , research degree student 1, Christopher T Rentsch , assistant professor 1, Rohini Mathur , assistant professor 1, Anna Schultze , research fellow 1, Nicholas J DeVito , researcher 2, Brian MacKenna , honorary research fellow pharmacist 2, William J Hulme , statistician 2, Richard Croker , pharmaceutical adviser 2, Alex J Walker , epidemiologist 2, Elizabeth J Williamson , professor 1, Chris Bates , director of research and analytics 3, Amir Mehrkar , senior clinical researcher 2, Helen J Curtis , researcher 2, David Evans , software developer 2, Kevin Wing , assistant professor 1, Peter Inglesby , consultant programmer 2, Henry Drysdale , research fellow 2, Angel Y S Wong , assistant professor 1, Jonathan Cockburn , software developer 3, Robert McManus , software developer 3, John Parry , clinical director 3, Frank Hester , founder and chief , executive officer 3, Sam Harper , software developer 3, Ian J Douglas , professor 1, Liam Smeeth , professor 1, Stephen J W Evans , professor 1, Krishnan Bhaskaran , professor 1, Rosalind M Eggo , associate professor 1 4, Ben Goldacre , director 2, Laurie A Tomlinson , associate professor 1 1Electronic Health Records Research Group, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK 2The DataLab, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford OX2 6GG, UK 3The Phoenix Partnership, 129 Low Lane, Horsforth, Leeds, UK 4Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, UK Correspondence to: B Goldacre p (or @bengoldacre on Twitter) Accepted 7 March 2021 Abstract Objective To investigate whether risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and outcomes of coronavirus disease 2019 (covid-19) differed between adults living with and without children during the first two waves of the UK pandemic.Results Among 9 334 392 adults aged 65 years and under, during wave 1, living with children was not associated with materially increased risks of recorded SARS-CoV-2 infection, covid-19 related hospital or intensive care admission, or death from covid-19.In wave 2, among adults aged 65 years and under, living with children of any age was associated with an increased risk of recorded SARS-CoV-2 infection (hazard ratio 1.08) for living with children aged 0-11 years; 1.

24) for living with children aged 12-18 years) and covid-19 related hospital admission (1.31) for living with children aged 0-11; 1.

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